19 articles - From Friday Dec 02 2022 to Friday Dec 09 2022
Guidelines and related publications, position statements, white papers, technical reviews, consensus statements, etc…
| Am J Kidney Dis |
Consensus Recommendations for Sick Day Medication Guidance for People With Diabetes, Kidney, or Cardiovascular Disease: A Modified Delphi Process. A multidisciplinary panel of clinicians reached a consensus on recommendations for SDMG in the presence of signs and symptoms of volume depletion, as well as self-management strategies and medication instructions in this setting. These recommendations may inform the design of future trials of SDMG strategies. |
meta-analyses and systematic reviews
RCT, clinical trials, retrospective studies, etc…
| Am J Kidney Dis |
SARS-CoV-2 Vaccine Effectiveness and Breakthrough Infections Among Patients Receiving Maintenance Dialysis. Among maintenance dialysis patients, SARS-CoV-2 vaccination was associated with a lower risk of COVID-19 diagnosis and associated hospitalization or death. Among vaccinated patients, low anti-spike IgG level is associated with worse COVID-19 related outcomes. |
| Clin J Am Soc Nephrol |
Use of Rituximab in Childhood Idiopathic Nephrotic Syndrome. Reliable immunophenotyping and biomarkers are yet to be discovered to predict treatment success, risk of both rare and severe side-effects, persistent hypogammaglobulinaemia and to guide on re-dosing strategy. In this review, we highlight recent advances on the use of rituximab for childhood nephrotic syndrome and how the therapeutic landscape is evolving. |
| Nephrol Dial Transplant |
Growth differentiation factor-15 (GDF-15) predicts major bleeding, major adverse cardiac events, and mortality in patients with end-stage kidney disease on hemodialysis: findings from the VIVALDI study. GDF-15 predicts risk of major bleeding, cardiovascular events, and death in ESKD patients on hemodialysis and might be a valuable marker to guide treatment decisions in this challenging patient population. |
Nonsteroidal mineralocorticoid receptor antagonists and cardiorenal outcomes in chronic kidney disease. Nonsteroidal MRAs have a unique pharmacological profile distinct from their steroidal counterparts, that retains the class-specific cardiorenal benefits but may help mitigate adverse effects, especially hyperkalemia, in patients with CKD. In this review, we summarize the current evidence in the use of non-steroidal MRAs for improving cardiorenal outcomes in patients with CKD and diabetes, as well as for combination use alongside other foundational medical therapies used in HF and CKD. |
Vitamin K supplementation and bone mineral density in dialysis: results of the double-blind, randomised, placebo-controlled RenaKvit trial. Compared with placebo, an accelerated BMD loss of the 1/3 distal radius was found after 2 years of MK-7 supplementation, whereas a decline in lumbar spine BMD was prevented. As such, MK-7 supplementation might modify BMD site-specifically in patients on dialysis. In aggregate, our findings do not support MK-7 supplementation to preserve bone in patients on dialysis. |
Plenty of the editorials are available as full text through the publisher website using the provided link
| Kidney Int |
Targeting inflammation to treat diabetic kidney disease: the road to 2030. Moreover, we review recent advances in the molecular regulation of inflammation in DKD and discuss potential novel therapeutic strategies with clinical relevance. Finally, we provide a roadmap for future research aimed at integrating the growing knowledge on inflammation and DKD into clinical practice to foster improvement of patient outcomes. |
| Nephrol Dial Transplant |
| Semin Nephrol |
Hidden in Plain Sight: Does Medullary Red Blood Cell Congestion Provide the Explanation for Ischemic Acute Kidney Injury? In this review, we argue that injury from outer medullary red blood cell congestion reflects the pathology observed in human kidneys and likely is representative of injury in most cases of ischemic AKI after shock. Greater focus on this congestive injury is likely to lead to improved translation in AKI. |
Risk Classification and Subphenotyping of Acute Kidney Injury: Concepts and Methodologies. For example, risk-classification should support actionable interventions that could ameliorate or prevent the occurrence of the outcome being predicted. Furthermore, subphenotyping could be applied to predict therapeutic responses to support enrichment and adaptive platforms for pragmatic clinical trials. |
misc publications eg case reports, tools of the trade, images of the month, etc…
| Kidney Int |
| Nat Rev Nephrol |
| Nephrol Dial Transplant |