Fri Dec 09 2022

19 articles - From Friday Dec 02 2022 to Friday Dec 09 2022

parm_toc.knit

Guidelines

Guidelines and related publications, position statements, white papers, technical reviews, consensus statements, etc…

Am J Kidney Dis

Consensus Recommendations for Sick Day Medication Guidance for People With Diabetes, Kidney, or Cardiovascular Disease: A Modified Delphi Process.

A multidisciplinary panel of clinicians reached a consensus on recommendations for SDMG in the presence of signs and symptoms of volume depletion, as well as self-management strategies and medication instructions in this setting. These recommendations may inform the design of future trials of SDMG strategies.

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Meta-analysis

meta-analyses and systematic reviews


Original articles

RCT, clinical trials, retrospective studies, etc…

Am J Kidney Dis

SARS-CoV-2 Vaccine Effectiveness and Breakthrough Infections Among Patients Receiving Maintenance Dialysis.

Among maintenance dialysis patients, SARS-CoV-2 vaccination was associated with a lower risk of COVID-19 diagnosis and associated hospitalization or death. Among vaccinated patients, low anti-spike IgG level is associated with worse COVID-19 related outcomes.

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Clin J Am Soc Nephrol

Use of Rituximab in Childhood Idiopathic Nephrotic Syndrome.

Reliable immunophenotyping and biomarkers are yet to be discovered to predict treatment success, risk of both rare and severe side-effects, persistent hypogammaglobulinaemia and to guide on re-dosing strategy. In this review, we highlight recent advances on the use of rituximab for childhood nephrotic syndrome and how the therapeutic landscape is evolving.

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Nephrol Dial Transplant

A single center in-depth analysis of death with a functioning kidney graft and reasons for overall graft failure.

DWF and DCGF share more causes for graft loss than previously reported, and sudden death plays an underestimated role in death with a functioning graft.

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Growth differentiation factor-15 (GDF-15) predicts major bleeding, major adverse cardiac events, and mortality in patients with end-stage kidney disease on hemodialysis: findings from the VIVALDI study.

GDF-15 predicts risk of major bleeding, cardiovascular events, and death in ESKD patients on hemodialysis and might be a valuable marker to guide treatment decisions in this challenging patient population.

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Nephrosclerosis in young patients with malignant hypertension.

The histopathological hallmark of nephrosclerosis was found alone in only 52% of study patients, regardless of ethnicity. This suggests that kidney biopsy might be beneficial in young patients with MH.

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Nonsteroidal mineralocorticoid receptor antagonists and cardiorenal outcomes in chronic kidney disease.

Nonsteroidal MRAs have a unique pharmacological profile distinct from their steroidal counterparts, that retains the class-specific cardiorenal benefits but may help mitigate adverse effects, especially hyperkalemia, in patients with CKD. In this review, we summarize the current evidence in the use of non-steroidal MRAs for improving cardiorenal outcomes in patients with CKD and diabetes, as well as for combination use alongside other foundational medical therapies used in HF and CKD.

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Vitamin K supplementation and bone mineral density in dialysis: results of the double-blind, randomised, placebo-controlled RenaKvit trial.

Compared with placebo, an accelerated BMD loss of the 1/3 distal radius was found after 2 years of MK-7 supplementation, whereas a decline in lumbar spine BMD was prevented. As such, MK-7 supplementation might modify BMD site-specifically in patients on dialysis. In aggregate, our findings do not support MK-7 supplementation to preserve bone in patients on dialysis.

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Reviews&Editorials

Plenty of the editorials are available as full text through the publisher website using the provided link

Kidney Int

Targeting inflammation to treat diabetic kidney disease: the road to 2030.

Moreover, we review recent advances in the molecular regulation of inflammation in DKD and discuss potential novel therapeutic strategies with clinical relevance. Finally, we provide a roadmap for future research aimed at integrating the growing knowledge on inflammation and DKD into clinical practice to foster improvement of patient outcomes.

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Nephrol Dial Transplant

Care about the flare: the importance of avoiding lupus nephritis recurrence.

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Semin Nephrol

Hidden in Plain Sight: Does Medullary Red Blood Cell Congestion Provide the Explanation for Ischemic Acute Kidney Injury?

In this review, we argue that injury from outer medullary red blood cell congestion reflects the pathology observed in human kidneys and likely is representative of injury in most cases of ischemic AKI after shock. Greater focus on this congestive injury is likely to lead to improved translation in AKI.

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Risk Classification and Subphenotyping of Acute Kidney Injury: Concepts and Methodologies.

For example, risk-classification should support actionable interventions that could ameliorate or prevent the occurrence of the outcome being predicted. Furthermore, subphenotyping could be applied to predict therapeutic responses to support enrichment and adaptive platforms for pragmatic clinical trials.

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Miscellaneous

misc publications eg case reports, tools of the trade, images of the month, etc…

Kidney Int

Estimating the prevalence of chronic kidney disease while accounting for non-random testing with inverse probability weighting.

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Nat Rev Nephrol

New insights into cognitive decline in chronic kidney disease.

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Progress towards solving the donor organ shortage.

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Nephrol Dial Transplant

Comparison of clinicopathological features between patients with and without hypocomplementemia in IgG4-related kidney disease.

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Exome sequencing-solved case in undetermined nephropathy with detection of TULP3-truncating variant.

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Steroid-sensitive nephrotic syndrome in children.

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Letters&Replies

Letters to the editors and authors’ replies

Am J Kidney Dis

Changes in Diet Quality, Risk of CKD Progression, and All-Cause Mortality in the CRIC Study.

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